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© Christophe HARGOUES / IGH / CNRS Images



Échantillons de cellules triées mis dans une centrifugeuse dans le laboratoire P3 de l'IGH

Sorted cell samples being placed in a centrifuge in the P3 laboratory at the Institute of Human Genetics (IGH). These cells will then be cultured (for the detection of viruses competent for viral replication) or used for molecular biology experiments (HIV-1 DNA qPCR to quantify the number of infected cells). It is in this laboratory that a marker has been identified that makes it possible to differentiate between dormant cells, infected with HIV (human immunodeficiency virus), and healthy cells. This discovery will make it possible to isolate and analyse these reservoir cells which, by silently hosting the virus, are responsible for its persistence even in patients receiving antiretroviral treatment, whose viral load is undetectable. It offers new therapeutic strategies for targeting infected cells.

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