© CNRS Images media 2002
There are continual exchanges between a cell's cytoplasm and its nucleus. In 1997, a team led by Catherine Dargemont of the Institut Jacques Monod was the first to develop a method for extracting proteins from the nucleus. Since then this laboratory has focused on several areas: the mechanisms regulating the exchanges; the mechanisms for transporting RNA and in particular the stage of translocation of the transport complexes in the cytoplasm; understanding how certain viruses like HIV make use of these exchange routes. A better understanding of the conditions for transport would make it possible to block it and thus to inhibit the replication of viruses.