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© Caroline DELMAS / Laetitia LIGAT / CRCT / CNRS Images



Brain galaxy

Glioblastoma is a brain tumour whose aggressive nature can be attributed to tumour stem cells. These cells, which are responsible for resistance to treatment, have the ability to form neurospheres and can enter neural differentiation pathways under certain culture conditions. Stem cells derived from human glioblastoma, clustered together in a neurosphere, can be seen in the image due to the labelling of the cell nuclei in blue. Through the action of growth factors, they adhere, migrate and differentiate, forming a ring around the initial sphere. As the cells move further away, they develop a phenotype similar to that of astrocytes, in green, or neurons, in red. The aim of such cell models is to optimise treatments and test new therapeutic approaches. This image was taken by confocal microscopy. It is one of the winners of the 2022 La preuve par l’image (LPPI) photography competition.

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