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© Serge VAN DE PAVERT / Carole SIRET / CIML / CNRS Images



Little monster

The embryonic development of lymph nodes, small organs that are essential for the immune response, is now well understood. Using light-sheet microscopy, scientists were able to determinethe processes at work in this 13.5-day-old mouse embryo. Shown in blue are the lymphoid cells (LTi), derived from the haemogenic endothelium, a tissue specific to the embryo. They move into the liver where they multiply and then migrate to the rest of the body, where they give rise to the lymph nodes. The 3D information obtained is used to track the interactions of the lymph nodes with their environment, in particular with nerve cells, in green, and blood vessels, in white. Lymphatic endothelial cells and some macrophages are displayed in red. This image was taken using light sheet microscopy. It is one of the winners of the 2022 La preuve par l’image (LPPI) photo competition.

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