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© Marina MALETIC / ICM / CNRS Images



Neural rosette

This mosaic of colours reveals the arrangement of stem cells inside a neural rosette. The image shows the interior of a brain organoid, a kind of miniature human brain created using stem cells from patients suffering from a form of hereditary epilepsy resistant to conventional antiepileptic drugs. The aim of this study model is to determine the role of a genetic mutation in the development of cortical malformations associated with the disease. Immunofluorescence makes it possible to distinguish normal neural stem cells, in red, from cells expressing the mutation, in green. This visual approach could be used in particular to test the effectiveness of new molecules intended to reduce epileptic seizures.

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