Métaphase anormale de Cellules HeLa
Cells in the process of dividing during the metaphase (i.e. the second phase in the mitotic cell-division sequence), observed using fluorescence microscopy. DNA is marked in blue, histone H3 in green, and cytochrome C (released by mitochondria upon cell death) in red. Here, scientists are analysing this stage of mitosis as part of a study into a particular type of cell-death: mitotic catastrophe. This phenomenon is caused either by a defect in the cell cycle sequence or by a DNA alteration. Accordingly, researchers observe the consequences of breaks on DNA, for example.