© Frédéric SAUDOU/SNC/CNRS Images

Couche épendymaire d'une souris modèle pour la maladie de Huntington, réalisée en microscopie à bala



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Max. size

10.84 x 8.67 cm / 300 dpi


The protein huntingtin controls ciliogenesis. When containing the pathogenic polyQ expansion, mutant huntingtin led to abnormally long primary cilia and disorganized cilia layers in mice and humans with Huntingon disease. Longer cilia resulted in alterations of the cerebrospinal fluid flow.

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