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Margaret Buckingham, a developmental biologist, is the 2013 CNRS Gold Medal laureate. Of Scottish descent, Buckingham graduated from Oxford University (UK) before obtaining a PhD in biology in 1971. After completing her postdoc at the Institut Pasteur, where she set up her own lab, she joined CNRS in 1975. Between 1987 and 2010, she was head of the "Molecular Genetics of Development" laboratory at the Institut Pasteur. Buckingham is a prominent figure in developmental biology research in the…

Margaret Buckingham, a developmental biologist, is the 2013 CNRS Gold Medal laureate. Of Scottish descent, Buckingham graduated from Oxford University (UK) before obtaining a PhD in biology in 1971. After completing her postdoc at the Institut Pasteur, where she set up her own lab, she joined CNRS in 1975. Between 1987 and 2010, she was head of the "Molecular Genetics of Development" laboratory at the Institut Pasteur. Buckingham is a prominent figure in developmental biology research in the…

Margaret Buckingham, a developmental biologist, is the 2013 CNRS Gold Medal laureate. Of Scottish descent, Buckingham graduated from Oxford University (UK) before obtaining a PhD in biology in 1971. After completing her postdoc at the Institut Pasteur, where she set up her own lab, she joined CNRS in 1975. Between 1987 and 2010, she was head of the "Molecular Genetics of Development" laboratory at the Institut Pasteur. Buckingham is a prominent figure in developmental biology research in the…

Margaret Buckingham, a developmental biologist, is the 2013 CNRS Gold Medal laureate. Of Scottish descent, Buckingham graduated from Oxford University (UK) before obtaining a PhD in biology in 1971. After completing her postdoc at the Institut Pasteur, where she set up her own lab, she joined CNRS in 1975. Between 1987 and 2010, she was head of the "Molecular Genetics of Development" laboratory at the Institut Pasteur. Buckingham is a prominent figure in developmental biology research in the…

Margaret Buckingham, a developmental biologist and CNRS 2013 Gold Medal laureate, and François Gros. Of Scottish descent, Buckingham graduated from Oxford University (UK) before obtaining a PhD in biology in 1971. After completing her postdoc at the Institut Pasteur, where she set up her own lab, she joined CNRS in 1975. Between 1987 and 2010, she was head of the "Molecular Genetics of Development" laboratory at the Institut Pasteur. Buckingham is a prominent figure in developmental biology…

Margaret Buckingham, a developmental biologist and CNRS 2013 Gold Medal laureate, and François Gros. Of Scottish descent, Buckingham graduated from Oxford University (UK) before obtaining a PhD in biology in 1971. After completing her postdoc at the Institut Pasteur, where she set up her own lab, she joined CNRS in 1975. Between 1987 and 2010, she was head of the "Molecular Genetics of Development" laboratory at the Institut Pasteur. Buckingham is a prominent figure in developmental biology…

Margaret Buckingham, a developmental biologist, is the 2013 CNRS Gold Medal laureate. Of Scottish descent, Buckingham graduated from Oxford University (UK) before obtaining a PhD in biology in 1971. After completing her postdoc at the Institut Pasteur, where she set up her own lab, she joined CNRS in 1975. Between 1987 and 2010, she was head of the "Molecular Genetics of Development" laboratory at the Institut Pasteur. Buckingham is a prominent figure in developmental biology research in the…

Margaret Buckingham, a developmental biologist, is the 2013 CNRS Gold Medal laureate. Of Scottish descent, Buckingham graduated from Oxford University (UK) before obtaining a PhD in biology in 1971. After completing her postdoc at the Institut Pasteur, where she set up her own lab, she joined CNRS in 1975. Between 1987 and 2010, she was head of the "Molecular Genetics of Development" laboratory at the Institut Pasteur. Buckingham is a prominent figure in developmental biology research in the…

Margaret Buckingham, a developmental biologist, is the 2013 CNRS Gold Medal laureate. Of Scottish descent, Buckingham graduated from Oxford University (UK) before obtaining a PhD in biology in 1971. After completing her postdoc at the Institut Pasteur, where she set up her own lab, she joined CNRS in 1975. Between 1987 and 2010, she was head of the "Molecular Genetics of Development" laboratory at the Institut Pasteur. Buckingham is a prominent figure in developmental biology research in the…

Margaret Buckingham, a developmental biologist, is the 2013 CNRS Gold Medal laureate. Of Scottish descent, Buckingham graduated from Oxford University (UK) before obtaining a PhD in biology in 1971. After completing her postdoc at the Institut Pasteur, where she set up her own lab, she joined CNRS in 1975. Between 1987 and 2010, she was head of the "Molecular Genetics of Development" laboratory at the Institut Pasteur. Buckingham is a prominent figure in developmental biology research in the…

Margaret Buckingham, a developmental biologist and CNRS 2013 Gold Medal laureate, and François Gros. Of Scottish descent, Buckingham graduated from Oxford University (UK) before obtaining a PhD in biology in 1971. After completing her postdoc at the Institut Pasteur, where she set up her own lab, she joined CNRS in 1975. Between 1987 and 2010, she was head of the "Molecular Genetics of Development" laboratory at the Institut Pasteur. Buckingham is a prominent figure in developmental biology…

Margaret Buckingham, a developmental biologist and CNRS 2013 Gold Medal laureate, and François Gros. Of Scottish descent, Buckingham graduated from Oxford University (UK) before obtaining a PhD in biology in 1971. After completing her postdoc at the Institut Pasteur, where she set up her own lab, she joined CNRS in 1975. Between 1987 and 2010, she was head of the "Molecular Genetics of Development" laboratory at the Institut Pasteur. Buckingham is a prominent figure in developmental biology…

Margaret Buckingham, a developmental biologist, is the 2013 CNRS Gold Medal laureate. Of Scottish descent, Buckingham graduated from Oxford University (UK) before obtaining a PhD in biology in 1971. After completing her postdoc at the Institut Pasteur, where she set up her own lab, she joined CNRS in 1975. Between 1987 and 2010, she was head of the "Molecular Genetics of Development" laboratory at the Institut Pasteur. Buckingham is a prominent figure in developmental biology research in the…

Margaret Buckingham, a developmental biologist, is the 2013 CNRS Gold Medal laureate. Of Scottish descent, Buckingham graduated from Oxford University (UK) before obtaining a PhD in biology in 1971. After completing her postdoc at the Institut Pasteur, where she set up her own lab, she joined CNRS in 1975. Between 1987 and 2010, she was head of the "Molecular Genetics of Development" laboratory at the Institut Pasteur. Buckingham is a prominent figure in developmental biology research in the…

Margaret Buckingham, a developmental biologist, is the 2013 CNRS Gold Medal laureate. Of Scottish descent, Buckingham graduated from Oxford University (UK) before obtaining a PhD in biology in 1971. After completing her postdoc at the Institut Pasteur, where she set up her own lab, she joined CNRS in 1975. Between 1987 and 2010, she was head of the "Molecular Genetics of Development" laboratory at the Institut Pasteur. Buckingham is a prominent figure in developmental biology research in the…

Margaret Buckingham, a developmental biologist and CNRS 2013 Gold Medal laureate, in her laboratory. Of Scottish descent, Buckingham graduated from Oxford University (UK) before obtaining a PhD in biology in 1971. After completing her postdoc at the Institut Pasteur, where she set up her own lab, she joined CNRS in 1975. Between 1987 and 2010, she was head of the "Molecular Genetics of Development" laboratory at the Institut Pasteur. Buckingham is a prominent figure in developmental biology…

Margaret Buckingham, a developmental biologist and CNRS 2013 Gold Medal laureate, in her laboratory. Of Scottish descent, Buckingham graduated from Oxford University (UK) before obtaining a PhD in biology in 1971. After completing her postdoc at the Institut Pasteur, where she set up her own lab, she joined CNRS in 1975. Between 1987 and 2010, she was head of the "Molecular Genetics of Development" laboratory at the Institut Pasteur. Buckingham is a prominent figure in developmental biology…

Margaret Buckingham, a developmental biologist and CNRS 2013 Gold Medal laureate, in her laboratory. Of Scottish descent, Buckingham graduated from Oxford University (UK) before obtaining a PhD in biology in 1971. After completing her postdoc at the Institut Pasteur, where she set up her own lab, she joined CNRS in 1975. Between 1987 and 2010, she was head of the "Molecular Genetics of Development" laboratory at the Institut Pasteur. Buckingham is a prominent figure in developmental biology…

Margaret Buckingham, a developmental biologist and CNRS 2013 Gold Medal laureate, in her laboratory. Of Scottish descent, Buckingham graduated from Oxford University (UK) before obtaining a PhD in biology in 1971. After completing her postdoc at the Institut Pasteur, where she set up her own lab, she joined CNRS in 1975. Between 1987 and 2010, she was head of the "Molecular Genetics of Development" laboratory at the Institut Pasteur. Buckingham is a prominent figure in developmental biology…

Margaret Buckingham, a developmental biologist and CNRS 2013 Gold Medal laureate, in her laboratory. Of Scottish descent, Buckingham graduated from Oxford University (UK) before obtaining a PhD in biology in 1971. After completing her postdoc at the Institut Pasteur, where she set up her own lab, she joined CNRS in 1975. Between 1987 and 2010, she was head of the "Molecular Genetics of Development" laboratory at the Institut Pasteur. Buckingham is a prominent figure in developmental biology…

Margaret Buckingham, a developmental biologist and CNRS 2013 Gold Medal laureate, in her laboratory. Of Scottish descent, Buckingham graduated from Oxford University (UK) before obtaining a PhD in biology in 1971. After completing her postdoc at the Institut Pasteur, where she set up her own lab, she joined CNRS in 1975. Between 1987 and 2010, she was head of the "Molecular Genetics of Development" laboratory at the Institut Pasteur. Buckingham is a prominent figure in developmental biology…

Margaret Buckingham, a developmental biologist and CNRS 2013 Gold Medal laureate, in her laboratory. Of Scottish descent, Buckingham graduated from Oxford University (UK) before obtaining a PhD in biology in 1971. After completing her postdoc at the Institut Pasteur, where she set up her own lab, she joined CNRS in 1975. Between 1987 and 2010, she was head of the "Molecular Genetics of Development" laboratory at the Institut Pasteur. Buckingham is a prominent figure in developmental biology…

Margaret Buckingham, a developmental biologist and CNRS 2013 Gold Medal laureate, in her laboratory. Of Scottish descent, Buckingham graduated from Oxford University (UK) before obtaining a PhD in biology in 1971. After completing her postdoc at the Institut Pasteur, where she set up her own lab, she joined CNRS in 1975. Between 1987 and 2010, she was head of the "Molecular Genetics of Development" laboratory at the Institut Pasteur. Buckingham is a prominent figure in developmental biology…

Margaret Buckingham, a developmental biologist and CNRS 2013 Gold Medal laureate, in her laboratory. Of Scottish descent, Buckingham graduated from Oxford University (UK) before obtaining a PhD in biology in 1971. After completing her postdoc at the Institut Pasteur, where she set up her own lab, she joined CNRS in 1975. Between 1987 and 2010, she was head of the "Molecular Genetics of Development" laboratory at the Institut Pasteur. Buckingham is a prominent figure in developmental biology…

Margaret Buckingham, a developmental biologist and CNRS 2013 Gold Medal laureate, in her laboratory. Of Scottish descent, Buckingham graduated from Oxford University (UK) before obtaining a PhD in biology in 1971. After completing her postdoc at the Institut Pasteur, where she set up her own lab, she joined CNRS in 1975. Between 1987 and 2010, she was head of the "Molecular Genetics of Development" laboratory at the Institut Pasteur. Buckingham is a prominent figure in developmental biology…

Margaret Buckingham, a developmental biologist and CNRS 2013 Gold Medal laureate, in her laboratory. Of Scottish descent, Buckingham graduated from Oxford University (UK) before obtaining a PhD in biology in 1971. After completing her postdoc at the Institut Pasteur, where she set up her own lab, she joined CNRS in 1975. Between 1987 and 2010, she was head of the "Molecular Genetics of Development" laboratory at the Institut Pasteur. Buckingham is a prominent figure in developmental biology…

Margaret Buckingham, a developmental biologist and CNRS 2013 Gold Medal laureate, in her laboratory. Of Scottish descent, Buckingham graduated from Oxford University (UK) before obtaining a PhD in biology in 1971. After completing her postdoc at the Institut Pasteur, where she set up her own lab, she joined CNRS in 1975. Between 1987 and 2010, she was head of the "Molecular Genetics of Development" laboratory at the Institut Pasteur. Buckingham is a prominent figure in developmental biology…

Transverse section of the muscle of a mouse. On the left, the green staining reveals the expression of the GFP protein (Green Fluorescent Protein), under the control of the Pax3 gene, in the nucleus of a myosatellite cell. On the right, the blue staining marks all the nuclei. The red staining, on both images, marks the presence of the extracellular matrix protein, laminin, around the fibers. The capacity of skeletal muscles to undergo regeneration depends on skeletal muscle stem cells, called…

Transverse sections of mouse skeletal muscles, with muscle fibers in red and their nuclei in blue. At the top, a non-injured muscle. The nuclei of the fibers are found at the periphery. The photograph at the bottom shows a regenerating muscle, 12 days after injury. Regenerating fibers have centrally located nuclei and many of them are smaller in size. The capacity of skeletal muscles to undergo regeneration depends on skeletal muscle stem cells, called myosatellite cells. Upon muscle injury,…

Immunomarquage des cellules d'un cœur d'embryon de souris. Il fait apparaître les contours des cellules en rouge, les noyaux en bleu et les axes de division des cellules en vert. L'analyse de ce type d'image a permis de conclure que les divisions cellulaires sont orientées au moment de l'expansion des chambres cardiaques.

Cœur d'un embryon de souris dans lequel une technique de marquage clonal a été utilisée pour révéler l'alignement des cellules (en bleu). Cette orientation de la croissance du muscle cardiaque permet de mieux comprendre comment le cœur se forme.

Muscle cardiaque d'un embryon de souris dans lequel une deuxième source de cellules (en bleu), importante pour la formation du ventricule droit, du pôle artériel et du pôle veineux, a été mise en évidence grâce à une analyse clonale du cœur. Les résultats de ces travaux permettent une meilleure compréhension de la cardiogenèse (formation du cœur) et ont des répercussions sur le diagnostic des maladies congénitales du cœur.

Detection of a myosatellite cell, on the surface of a single fiber of a mouse muscle. At the top, the blue staining shows all the nuclei present either inside or outside the fiber. At the bottom, the green staining shows the specific expression of the Pax7 protein in the nucleus of a myosatellite cell present on the surface of the fiber. The capacity of skeletal muscles to undergo regeneration depends on skeletal muscle stem cells, called myosatellite cells. Upon muscle injury, myosatellite…