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Cells treated with Paclitaxel have increased Detyr-microtubule content. HeLa cells were treated for 2 hours with 5 µM of paclitaxel (Taxol®) a known microtubule stabilizing agent. Stabilized microtubules (green) are visualized using a Detyr-tubulin antibody. Actin microfilaments (red) are stained with fluorescent phalloidin and cell nuclei are stained in blue, using Hoechst reagent.

Cells treated with LIMK inhibitor Pyr1 have increased Detyr-microtubule content. HeLa cells were treated for 2 hours with 25 µM of Pyr1, the newly discovered LIMK inhbitor. Stabilized microtubules (green) are visualized using a Detyr-tubulin antibody. Mitochondria (red) are stained using mitotracker ® and cell nuclei are stained in blue, using Hoechst reagent