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Mad cow disease, like other neurodegenerative diseases, is probably due to the presence of an abnormal form of the prion, a protein found in mammalian nerve cells. A collaborative project by a team of biochemists from the Laboratoire d'enzymologie et biochimie structurale in Gif-sur-Yvette and a team of physicists from the ESRF (European Synchrotron Radiation Facility) in Grenoble has led to an understanding of the three-dimensional structure of the yeast prion.The prion crystals are positioned…